Early relationships between European newcomers and Native Americans living in the Pacific Northwest certainly went no better than in most other regions of the Americas.  European supremacy became much easier through early introduction of disease, an actual prelude in many cases to actual ethnic introductions.  Bad as the era directly before the two peoples came together face to face was, disease continued to inflict the Native populations, a factor leading directly to ill will and what became known as the “Cayuse War” in 1847.